Sensitivity, Specificity, Positive Predictive Value, & Negative Predictive Value Please review this Excel spreadsheet: Week 2 Epidemiological Examples (please see at

/ Anatomy / By

Sensitivity, Specificity, Positive Predictive Value, & Negative Predictive Value

Please review this Excel spreadsheet: Week 2 Epidemiological Examples (please see attached document)

In your post, you are to select a disease that no one else has selected. You can post early in the week to reserve your disease and then just reply to your original post when your material is done. Answer the following questions with your initial post.

1. What disease did you select? (Liver and pancreatic cancer

2. Find two different incidence rates for this disease. This can be either the rates of the disease in two different countries, age groups, ethnicities, occupation, or any other classifier that might be important to your disease. Provide the two different rates here. Cite your source.

3. Select a screening test or a confirmatory test for your disease. Report on what the sensitivity and specificity percentages are and cite your source. Also, provide the cost of the test.

4. Using the method outlined in the excel document determine the PPV and NPV of using both screening tests in the two populations you selected.

5. How much did each true positive cost?

6. Does it make sense to implement mandatory screening in either population? Why or why not?

Sen & Spec

Example 1
Disease (+) Disease (-)
Test (+) a (True Positive) b (False Positive) All Test Positive
Test (-) c (False Neg) d (True Negative) All Test Negative
All Diseased All Well Total Pop
Sensitivity 90% a/a+c
Specificity 95% d/d+b
Fake Data on an UNKNOWN DISEASE AND TEST
Disease (+) Disease (-)
Test (+) 475 4974 5449
Test (-) 53 94499 94551
528 99472 100000

What you see below is a 2 x 2 table. We will be using it to explain how to calculate sensitivity and specificity. Once that is explained, we will move on how to use sensitivity and specificity data along with incidence information to estamate how many people will be found using a screening program.

As you can see from our fictitious example, the fake screening test that we are talking about using would give 53 people a negative result when they were sick, 4,974 a positive result when they were not sick. This doesn’t sound like a great test, but that is all dependent on the natural history of the disease, mortality associated with it, and the communibility.

Please continue to the next sheet labeled PPV & NPV.

PPV & NPV

Example 1
Disease (+) Disease (-)
Test (+) Sensitivity (a) 1 – Specificity (b) All Test Positive
Test (-) 1 – Sensitivity ( c ) Specificity (d) All Test Negative
Incidence Number Population -Incidence Number Total Pop
PPV = A/A+B
NPV = D/D+C
Step 1: Insert Sensitivity and Specificity
Disease (+) Disease (-)
Test (+) 90% 1 – Specificity (b) All Test Positive
Test (-) 1 – Sensitivity ( c ) 95% All Test Negative
Incidence Number Population -Incidence Number Total Pop
Step 2: Calculate C & D
Disease (+) Disease (-)
Test (+) 90% 5% All Test Positive
Test (-) 10% 95% All Test Negative
Incidence Number Popul
Sensitivity, Specificity, Positive Predictive Value, & Negative Predictive Value Please review this Excel spreadsheet: Week 2 Epidemiological Examples (please see attached document) In your post, you are to select a disease that no one else has selected. You can post early in the week to reserve your disease and then just reply to your original post when your material is done. Answer the following questions with your initial post. 1. What disease did you select? (Liver and pancreatic cancer 2. Find two different incidence rates for this disease. This can be either the rates of the disease in two different countries, age groups, ethnicities, occupation, or any other classifier that might be important to your disease. Provide the two different rates here. Cite your source. 3. Select a screening test or a confirmatory test for your disease. Report on what the sensitivity and specificity percentages are and cite your source. Also, provide the cost of the test. 4. Using the method outlined in the excel document determine the PPV and NPV of using both screening tests in the two populations you selected. 5. How much did each true positive cost? 6. Does it make sense to implement mandatory screening in either population? Why or why not? Sen & Spec Example 1 Disease (+) Disease (-) Test (+) a (True Positive) b (False Positive) All Test Positive Test (-) c (False Neg) d (True Negative) All Test Negative All Diseased All Well Total Pop Sensitivity 90% a/a+c Specificity 95% d/d+b Fake Data on an UNKNOWN DISEASE AND TEST Disease (+) Disease (-) Test (+) 475 4974 5449 Test (-) 53 94499 94551 528 99472 100000 What you see below is a 2 x 2 table. We will be using it to explain how to calculate sensitivity and specificity. Once that is explained, we will move on how to use sensitivity and specificity data along with incidence information to estamate how many people will be found using a screening program. As you can see from our fictitious example, the fake screening test that we are talking about using would give 53 people a negative result when they were sick, 4,974 a positive result when they were not sick. This doesn’t sound like a great test, but that is all dependent on the natural history of the disease, mortality associated with it, and the communibility. Please continue to the next sheet labeled PPV & NPV. PPV & NPV Example 1 Disease (+) Disease (-) Test (+) Sensitivity (a) 1 – Specificity (b) All Test Positive Test (-) 1 – Sensitivity ( c ) Specificity (d) All Test Negative Incidence Number Population -Incidence Number Total Pop PPV = A/A+B NPV = D/D+C Step 1: Insert Sensitivity and Specificity Disease (+) Disease (-) Test (+) 90% 1 – Specificity (b) All Test Positive Test (-) 1 – Sensitivity ( c ) 95% All Test Negative Incidence Number Population -Incidence Number Total Pop Step 2: Calculate C & D Disease (+) Disease (-) Test (+) 90% 5% All Test Positive Test (-) 10% 95% All Test Negative Incidence Number Popul

Why Choose Us

  • 100% non-plagiarized Papers
  • 24/7 /365 Service Available
  • Affordable Prices
  • Any Paper, Urgency, and Subject
  • Will complete your papers in 6 hours
  • On-time Delivery
  • Money-back and Privacy guarantees
  • Unlimited Amendments upon request
  • Satisfaction guarantee

How it Works

  • Click on the “Place Your Order” tab at the top menu or “Order Now” icon at the bottom and a new page will appear with an order form to be filled.
  • Fill in your paper’s requirements in the "PAPER DETAILS" section.
  • Fill in your paper’s academic level, deadline, and the required number of pages from the drop-down menus.
  • Click “CREATE ACCOUNT & SIGN IN” to enter your registration details and get an account with us for record-keeping and then, click on “PROCEED TO CHECKOUT” at the bottom of the page.
  • From there, the payment sections will show, follow the guided payment process and your order will be available for our writing team to work on it.